Enriched Environment Facilitates Anxiolytic Efficacy Driven by Deep-Brain Stimulation of Medial Prefrontal Cortex.

Yamini Bhaskar, Lee Wei Lim, Rupshi Mitra

Front. Behav. Neurosci., 09 October 2018 |

Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons.

Ashokan A, Lim JWH, Hang N, Mitra R.

Sci Rep. 2018 May 9;8(1):7308. doi: 10.1038/s41598-018-25399-4.

F1000 - Post-publication peer review

Effects of stress or infection on rat behavior show robust reversals due to environmental disturbance.

Abdulai-Saiku S, Hegde A, Vyas A, Mitra R.

Version 2. F1000Res. 2017 Dec 6 [revised 2018 Jan 1];6:2097. doi: 10.12688/f1000research.13171.2. eCollection 2017.

Housing environment influences stress-related hippocampal substrates and depression-like behavior.

Ashokan A, Hegde A, Balasingham A, Mitra R.

Brain Res. 2018 Mar 15;1683:78-85. doi: 10.1016/j.brainres.2018.01.021. Epub 2018 Feb 2.

Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress.

Hegde A, Soh Yee P, Mitra R.

Int J Environ Res Public Health. 2017 Jul 14;14(7). pii: E779. doi: 10.3390/ijerph14070779.

Short-term environmental enrichment is sufficient to counter stress-induced anxiety and associated structural and molecular plasticity in basolateral amygdala.

Ashokan A, Hegde A, Mitra R.

Psychoneuroendocrinology. 2016 Jul;69:189-96. doi: 10.1016/j.psyneuen.2016.04.009. Epub 2016 Apr 11.

Short environmental enrichment in adulthood reverses anxiety and basolateral amygdala hypertrophy induced by maternal separation.

Koe AS, Ashokan A, Mitra R.

Transl Psychiatry. 2016 Feb 2;6:e729. doi: 10.1038/tp.2015.217.

Short-term enrichment makes male rats more attractive, more defensive and alters hypothalamic neurons.

Mitra R, Sapolsky RM.

PLoS One. 2012;7(5):e36092. doi: 10.1371/journal.pone.0036092. Epub 2012 May 2.


Seeding Stress Resilience through Inoculation.

Ashokan A, Sivasubramanian M, Mitra R.

Neural Plast. 2016;2016:4928081. doi: 10.1155/2016/4928081. Epub 2016 Jan 5. Review.

Toxoplasma gondii infection induces dendritic retraction in basolateral amygdala accompanied by reduced corticosterone secretion.

Mitra R, Sapolsky RM, Vyas A.

Dis Model Mech. 2013 Mar;6(2):516-20. doi: 10.1242/dmm.009928. Epub 2012 Oct 25.


Short-term enrichment makes male rats more attractive, more defensive and alters hypothalamic neurons.

Mitra R, Sapolsky RM.

PLoS One. 2012;7(5):e36092. doi: 10.1371/journal.pone.0036092. Epub 2012 May 2.


Stress coping stimulates hippocampal neurogenesis in adult monkeys.

Lyons DM, Buckmaster PS, Lee AG, Wu C, Mitra R, Duffey LM, Buckmaster CL, Her S, Patel PD, Schatzberg AF.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14823-7. doi: 10.1073/pnas.0914568107. Epub 2010 Jul 30.


Gene therapy in rodent amygdala against fear disorders.

Mitra R, Sapolsky RM.

Expert Opin Biol Ther. 2010 Sep;10(9):1289-303. doi: 10.1517/14712598.2010.509341. Review.


Expression of chimeric estrogen-glucocorticoid-receptor in the amygdala reduces anxiety.

Mitra R, Sapolsky RM.

Brain Res. 2010 Jun 25;1342:33-8. doi: 10.1016/j.brainres.2010.03.092. Epub 2010 Apr 8.


Resilience against predator stress and dendritic morphology of amygdala neurons.

Mitra R, Adamec R, Sapolsky R.

Behav Brain Res. 2009 Dec 28;205(2):535-43. doi: 10.1016/j.bbr.2009.08.014. Epub 2009 Aug 15.


Mineralocorticoid receptor overexpression in basolateral amygdala reduces corticosterone secretion and anxiety.

Mitra R, Ferguson D, Sapolsky RM.

Biol Psychiatry. 2009 Oct 1;66(7):686-90. doi: 10.1016/j.biopsych.2009.04.016. Epub 2009 Jun 5.


Effects of enrichment predominate over those of chronic stress on fear-related behavior in male rats.

Mitra R, Sapolsky RM.

Stress. 2009 Jul;12(4):305-12. doi: 10.1080/10253890802379955.


Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy.

Mitra R, Sapolsky RM.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5573-8. doi: 10.1073/pnas.0705615105. Epub 2008 Apr 7.


Social stress-related behavior affects hippocampal cell proliferation in mice.

Mitra R, Sundlass K, Parker KJ, Schatzberg AF, Lyons DM.

Physiol Behav. 2006 Sep 30;89(2):123-7. Epub 2006 Jul 11.


Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala.

Mitra R, Jadhav S, McEwen BS, Vyas A, Chattarji S.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9371-6. Epub 2005 Jun 20.

Chronic-stress induced modulation of different states of anxiety-like behavior in female rats.

Mitra R, Vyas A, Chatterjee G, Chattarji S.

Neurosci Lett. 2005 Aug 5;383(3):278-83. Epub 2005 Apr 26.


Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons.

Vyas A, Mitra R, Shankaranarayana Rao BS, Chattarji S.

J Neurosci. 2002 Aug 1;22(15):6810-8.